Preparation And Characterization Of Novel Spin Labeled Magnetic Nanoparticles
Hongli Zhao, Zhigang Zhang, Zijun Zhao, Ronghua Yu, Yuanyuan Wan, Minbo Lan
Volume 2, Issue 3, Page 172-175 | DOI: 10.5185/amlett.2011.1210
Multifunctional magnetic nanoparticles (MNPs); spin labeled; electron paramagnetic resonance (EPR); bio-probes; drug delivery
Novel spin-labeled magnetic nanoparticles (MNPs) were prepared through the reaction between carboxylic acids modified Fe3O4 particles and 4-amino-2,2,6,6-tetramethylpiperidin-1-oxyl (4-NH2-TEMPO). And X-ray diffractometer (XRD), FT-IR spectra, thermogravimetric analysis (TGA), transmission electronic microscopy (TEM) and room temperature electron paramagnetic resonance (EPR) were employed to characterize the prepared materials. The results of EPR measurements indicated that the spin labeled MNPs exhibited both the paramagnetism of nitroxide free radicals and superparamagnetism of ferrimagnetic nanoparticles could act as a bio-probe or potential drug delivery vehicles tracking by EPR technique. Copyright © 2011 VBRI press.